Noradrenaline release in human corpus cavernosum and its modulation via presynaptic alpha 2-adrenoceptors

Fundam Clin Pharmacol. 1989;3(5):497-504. doi: 10.1111/j.1472-8206.1989.tb00684.x.


Strips of human corpus cavernosum were incubated with 3H-noradrenaline and subsequently superfused with physiological salt solution containing desipramine and corticosterone. The electrically (0.66 Hz) evoked tritium overflow was abolished by tetrodotoxin or omission of Ca2+ from the superfusion fluid. The alpha 2-adrenoceptor agonist B-HT 920 (6-allyl-2-amino-5, 6, 7, 8-4H-thiazolo-5,4-d-azepine), inhibited the evoked overflow, whereas the alpha 1-adrenoceptor agonist, methoxamine, was ineffective. The alpha 2-adrenoceptor antagonist, rauwolscine, facilitated the evoked tritium overflow. It is concluded that the stimulation-evoked release of noradrenaline from the sympathetic nerve fibres of the human corpus cavernosum is modulated via presynaptic alpha 2-adrenoceptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenergic alpha-Agonists / pharmacology
  • Adrenergic alpha-Antagonists / pharmacology
  • Adult
  • Electric Stimulation
  • Humans
  • In Vitro Techniques
  • Male
  • Middle Aged
  • Norepinephrine / metabolism*
  • Penis / innervation
  • Penis / metabolism*
  • Penis / physiology
  • Receptors, Adrenergic, alpha / metabolism*
  • Sympathetic Nervous System / metabolism*
  • Synapses / drug effects
  • Synapses / metabolism


  • Adrenergic alpha-Agonists
  • Adrenergic alpha-Antagonists
  • Receptors, Adrenergic, alpha
  • Norepinephrine