The origin of HLA-DR"Br": exon 2 nucleotide sequence implicates possible gene conversion of DR1 by DR4-Dw10, DR5, or DRw6-Dw18

Hum Immunol. 1989 Nov;26(3):191-7. doi: 10.1016/0198-8859(89)90038-4.

Abstract

The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated from DR1 by gene conversion with DR4-Dw10, DR5, or DRw6-Dw18 third hypervariable region sequences.

Publication types

  • Comparative Study

MeSH terms

  • Base Sequence
  • Cell Line
  • Cloning, Molecular
  • DNA
  • DNA-Directed DNA Polymerase
  • Exons*
  • Gene Conversion*
  • HLA-DR Antigens / genetics*
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length

Substances

  • HLA-DR Antigens
  • DNA
  • DNA-Directed DNA Polymerase