Spatial and temporal dynamics of the cardiac mitochondrial proteome

Expert Rev Proteomics. 2015 Apr;12(2):133-46. doi: 10.1586/14789450.2015.1024227. Epub 2015 Mar 9.


Mitochondrial proteins alter in their composition and quantity drastically through time and space in correspondence to changing energy demands and cellular signaling events. The integrity and permutations of this dynamism are increasingly recognized to impact the functions of the cardiac proteome in health and disease. This article provides an overview on recent advances in defining the spatial and temporal dynamics of mitochondrial proteins in the heart. Proteomics techniques to characterize dynamics on a proteome scale are reviewed and the physiological consequences of altered mitochondrial protein dynamics are discussed. Lastly, we offer our perspectives on the unmet challenges in translating mitochondrial dynamics markers into the clinic.

Keywords: cardiovascular disease; mitochondria; protein dynamics; spatial dynamics; temporal dynamics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Humans
  • Mitochondria / metabolism*
  • Mitochondrial Proteins / metabolism*
  • Myocardium / metabolism*
  • Proteome / metabolism*
  • Proteomics


  • Biomarkers
  • Mitochondrial Proteins
  • Proteome