Sublingual immunotherapy in children and its potential beneficial collateral effect on respiratory tract infections

Curr Med Res Opin. 2015 May;31(5):939-41. doi: 10.1185/03007995.2015.1027182. Epub 2015 Mar 31.


Although directed to the control of allergic symptoms, a possible effect of sublingual immunotherapy (SLIT) on susceptibility to infections has been hypothesized. Two hundred sixty-five children aged between 3 and 4 years of age affected by allergic rhinitis completed a 6 year prospective case-control study. One hundred forty-three children after 2 years of SLIT reported a lower prevalence of respiratory tract infections when compared to children not undergoing SLIT.

Keywords: Antibiotics; Children; Respiratory infections; Sublingual immunotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Sublingual
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Prospective Studies
  • Respiratory Tract Infections / immunology
  • Respiratory Tract Infections / therapy*
  • Rhinitis, Allergic / immunology
  • Rhinitis, Allergic / therapy*
  • Sublingual Immunotherapy / methods*
  • Treatment Outcome