Abstract
We investigated the effects of dietary iron deficiency on the redox system in the heart. Dietary iron deficiency increased heart weight and accumulation of carbonylated proteins. However, expression levels of heme oxygenase-1 and LC3-II, an antioxidant enzyme and an autophagic marker, respectively, in iron-deficient mice were upregulated compared to the control group, resulting in a surrogate phenomenon against oxidative stress.
Keywords:
antioxidant enzyme; autophagy; heart; iron deficiency; oxidative stress.
MeSH terms
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Adaptor Proteins, Signal Transducing / biosynthesis*
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Adaptor Proteins, Signal Transducing / genetics
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Animals
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Antioxidants / metabolism
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Autophagy / drug effects
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Cytoskeletal Proteins / biosynthesis*
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Cytoskeletal Proteins / genetics
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Gene Expression Regulation / drug effects
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Heart / drug effects
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Heme Oxygenase-1 / biosynthesis*
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Heme Oxygenase-1 / genetics
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Humans
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Iron Deficiencies
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Iron, Dietary / administration & dosage*
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Kelch-Like ECH-Associated Protein 1
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Mice
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Myocardium / metabolism*
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NF-E2-Related Factor 2 / biosynthesis*
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NF-E2-Related Factor 2 / genetics
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Oxidative Stress / drug effects
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Signal Transduction / drug effects
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Superoxide Dismutase / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Antioxidants
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Cytoskeletal Proteins
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Iron, Dietary
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Keap1 protein, mouse
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Kelch-Like ECH-Associated Protein 1
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NF-E2-Related Factor 2
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Nfe2l2 protein, mouse
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Heme Oxygenase-1
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Superoxide Dismutase