Expression data analysis with Reactome

Curr Protoc Bioinformatics. 2015 Mar 9;49:8.20.1-8.20.9. doi: 10.1002/0471250953.bi0820s49.


The Reactome database of curated biological pathways provides a tool for visualizing user-supplied expression data as an overlay on pathway diagrams, thereby affording an effective means to examine expression of the constituents of the pathway and determine whether all that are necessary are present. Several experiments can be visualized in succession, to determine whether expression changes with experimental conditions, a useful feature for examining a time-course, dose-response, or disease progression.

Keywords: expression analysis; microarray; pathway; quantitative proteomics; reactome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Regulation*
  • Humans
  • Oligonucleotide Array Sequence Analysis
  • Signal Transduction / genetics*
  • Statistics as Topic*
  • User-Computer Interface