Relationship between 11β-HSD2 mRNA and insulin sensitivity in term small-for-gestational age neonates after birth

Int J Clin Exp Pathol. 2015 Jan 1;8(1):928-32. eCollection 2015.


The aim of this study was to investigate the relationship between serum 11β-HSD2 mRNA level and insulin sensitivity in term small-for-gestational age (SGA) neonates after birth. The 38 infants were divided into two groups, the SGA group and the appropriate-for-gestational age (AGA) group. The placental 11β-HSD2 mRNA abundance and concentration of cortisol, fasting glucose, fasting insulin, adiponectin, visfatin and insulin-like growth factor-I (IGF-1) in the umbilical vein plasma were measured. The results showed that in the SGA group, neonates had lower levels of placental 11β-HSD2 mRNA and serum cortisol, and higher fasting insulin and HOMA-IR compared to AGA group. For some insulin sensitivity relative factor, levels of serum adiponectin and IGF-1 were lower while visfatin was higher in the SGA group than AGA group. Correlation analyses revealed that 11β-HSD2 mRNA level had a negative correlation with fasting insulin, HOMA-IR and visfatin.

Keywords: 11β-HSD2; SGA; insulin sensitivity; neonates; term.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 11-beta-Hydroxysteroid Dehydrogenase Type 2 / metabolism*
  • Adiponectin / metabolism
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Small for Gestational Age / metabolism*
  • Insulin Resistance / physiology*
  • Male
  • Nicotinamide Phosphoribosyltransferase / metabolism
  • RNA, Messenger / analysis
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction


  • Adiponectin
  • RNA, Messenger
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2
  • HSD11B2 protein, human
  • Nicotinamide Phosphoribosyltransferase