Metachronous metastasis from the right colon adenocarcinoma to the vulva: an unusual report and literature review

Int J Clin Exp Pathol. 2015 Jan 1;8(1):1000-6. eCollection 2015.


A 67-year-old woman who was presented to the gynecologist with a two-month history of heavy vaginal bleeding, after an excisional biopsy of vulvar mass, was diagnosed with the right colon adenocarcinoma metachronous metastasis to the vulva. Pathological examination preliminarily revealed by primary adenosquamous carcinoma of vulva. The original submitting pathologist and gynecologist were contacted to obtain the pathological and clinical information whenever possible, combining with a history of the right colon cancer, subsequently, which confirmed the diagnosis of vulvar metastatic adenocarcinoma. Distinguishing metastatic carcinoma from primary vulvar adenocarcinoma is crucial, since these carcinomas are different. Herein reports the second case of the right colon carcinoma presenting as a vulvar metastasis. This report also shows the differentiation, diagnosis and treatment of metastatic colon carcinoma and its metastatic route.

Keywords: Colon adenocarcinoma; differentiation; metachronous metastasis; metastatic route; treatment; vulvar adenocarcinoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / secondary*
  • Aged
  • Colonic Neoplasms / pathology*
  • Female
  • Humans
  • Vulvar Neoplasms / secondary*