Localized myxedema on the nasal dorsum in a patient with Graves' disease: report of a case

J Endocrinol Invest. 1989 Nov;12(10):717-21. doi: 10.1007/BF03350040.


We report the case of a 56-year-old Japanese female with Graves' disease associated with localized myxedema on the nasal dorsum. The patient developed localized myxedema concomitantly with hyperthyroidism before antithyroid therapy was given. The lesion was totally removed surgically, as it was small and well circumscribed. Although unusual locations of localized myxedema have been reported elsewhere, there is to date no case of localized myxedema on the nasal dorsum without involvement of the pretibial area reported in the literature. We discuss this unique feature of our patient.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood
  • Female
  • Graves Disease / complications*
  • Humans
  • Immunoglobulins, Thyroid-Stimulating
  • Middle Aged
  • Myxedema / complications*
  • Nose*
  • Thyroxine / blood
  • Triiodothyronine / blood


  • Autoantibodies
  • Immunoglobulins, Thyroid-Stimulating
  • Triiodothyronine
  • Thyroxine