Oral allergy syndrome (pollen-food allergy syndrome)

Dermatitis. Mar-Apr 2015;26(2):78-88. doi: 10.1097/DER.0000000000000087.


Oral allergy syndrome (OAS) or pollen-food allergy syndrome (PFS) is a hypersensitivity reaction to plant-based foods, manifesting most commonly with pruritus of the lips, tongue, and mouth. Unlike simple food allergy, OAS requires prior sensitization to a cross-reacting inhalant allergen rather than direct sensitization to a specific food protein. In this review, we summarize the clinical features and pathophysiology of OAS and provide an overview of known pollen-food associations.

Publication types

  • Review

MeSH terms

  • Cross Reactions / immunology
  • Eating
  • Food Hypersensitivity / etiology*
  • Food Hypersensitivity / immunology
  • Fruit / adverse effects*
  • Fruit / immunology
  • Humans
  • Inhalation Exposure
  • Mouth Diseases / etiology*
  • Mouth Diseases / immunology
  • Pruritus / etiology*
  • Pruritus / immunology
  • Rhinitis, Allergic, Seasonal / etiology*
  • Rhinitis, Allergic, Seasonal / immunology
  • Vegetables / adverse effects*
  • Vegetables / immunology