Childhood obesity: immune response and nutritional approaches

Front Immunol. 2015 Feb 24:6:76. doi: 10.3389/fimmu.2015.00076. eCollection 2015.


Childhood obesity is characterized by a low-grade inflammation status depending on the multicellular release of cytokines, adipokines, and reactive oxygen species. In particular, the imbalance between anti-inflammatory T regulatory cells and inflammatory T helper 17 cells seems to sustain such a phlogistic condition. Alterations of gut microbiota since childhood also contribute to the maintenance of inflammation. Therefore, besides preventive measures and caloric restrictions, dietary intake of natural products endowed with anti-oxidant and anti-inflammatory activities may represent a valid interventional approach for preventing and/or attenuating the pathological consequences of obesity. In this regard, the use of prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, and melatonin in human clinical trials will be described.

Keywords: atherosclerosis; children; diabetes; immunity; microbiota; nutrition; obesity; oxidative stress.

Publication types

  • Review