Concurrent primary peritoneal low-grade serous carcinoma and endometrial high-grade serous carcinoma

Int J Gynecol Pathol. 2015 May;34(3):288-92. doi: 10.1097/PGP.0000000000000133.


A 64-yr-old postmenopausal woman with high-grade squamous intraepithelial lesion and atypical glandular cell of undetermined significance on her Pap test was found to have endometrial serous carcinoma (high grade) involving a polyp in a subsequent endometrial biopsy. She underwent hysterectomy and bilateral salpingo-oophorectomy with multiple biopsies of the peritoneum. Microscopic examination of the entirely submitted uterus showed no residual serous carcinoma. Multiple foci of low-grade serous tumor with extensive calcifications and psammoma bodies were identified on the surfaces of the left fallopian tube, ovaries, and biopsies of the peritoneum, consistent with peritoneal primary low-grade serous carcinoma. To our knowledge, this is the first reported case of low-grade serous carcinoma of the peritoneum with a concurrent (high-grade) serous carcinoma of the endometrium arising from an endometrial polyp.

Publication types

  • Case Reports

MeSH terms

  • Cystadenocarcinoma, Serous / pathology*
  • Endometrial Neoplasms / pathology*
  • Fallopian Tube Neoplasms / pathology
  • Female
  • Humans
  • Neoplasm Grading
  • Neoplasms, Multiple Primary / pathology*
  • Ovarian Neoplasms / pathology
  • Peritoneal Neoplasms / pathology*
  • Polyps / pathology*