[Sarcoma of the hand and wrist]

Handchir Mikrochir Plast Chir. 2015 Apr;47(2):76-82. doi: 10.1055/s-0034-1398527. Epub 2015 Mar 11.
[Article in German]

Abstract

Sarcomas of the hand and wrist are rare malignancies, which should be referred to high-volume comprehensive cancer centres providing multidisciplinary treatment options. The tumour board should propose patient-oriented oncological pathways as well as sophisticated hand and plastic reconstructive procedures. In Addition, isolated limb perfusion with TNF-alpha and melphalan is likely to lead to preoperative tumour shrinkage allowing for R0 resection in sano. Our clinical results in long-term survivors demonstrate reduced amputation rates and salvage of basic hand function when a risk-adapted treatment rationale is applied.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Amputation / methods
  • Bone Neoplasms / pathology
  • Bone Neoplasms / therapy*
  • Chemotherapy, Cancer, Regional Perfusion / methods
  • Combined Modality Therapy
  • Cooperative Behavior*
  • Female
  • Hand / pathology
  • Hand / surgery*
  • Humans
  • Interdisciplinary Communication*
  • Limb Salvage / methods
  • Male
  • Melphalan / administration & dosage
  • Middle Aged
  • Neoadjuvant Therapy
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Neoplasm Staging
  • Prognosis
  • Radiotherapy, Adjuvant
  • Reconstructive Surgical Procedures / methods*
  • Sarcoma / pathology
  • Sarcoma / therapy*
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / therapy*
  • Tumor Necrosis Factor-alpha / administration & dosage
  • Wrist / pathology
  • Wrist / surgery*

Substances

  • Tumor Necrosis Factor-alpha
  • Melphalan