Multiparametric ultrasound in the detection of prostate cancer: a systematic review

World J Urol. 2015 Nov;33(11):1651-9. doi: 10.1007/s00345-015-1523-6. Epub 2015 Mar 12.


Purpose: To investigate the advances and clinical results of the different ultrasound modalities and the progress in combining them into multiparametric UltraSound (mpUS).

Methods: A systematic literature search on mpUS and the different ultrasound modalities included: greyscale ultrasound, computerized transrectal ultrasound, Doppler and power Doppler techniques, dynamic contrast-enhanced ultrasound and (shear wave) elastography.

Results: Limited research available on combining ultrasound modalities has presented improvement in diagnostic performance. The data of two studies suggest that even adding a lower performing ultrasound modality to a better performing modality using crude methods can already improve the sensitivity by 13-51 %. The different modalities detect different tumours. No study has tried to combine ultrasound modalities employing a system similar to the PIRADS system used for mpMRI or more advanced classifying algorithms.

Conclusion: Available evidence confirms that combining different ultrasound modalities significantly improves diagnostic performance.

Keywords: ANNA/C-TRUS; Contrast-enhanced ultrasound; Doppler; Elastography; Multiparametric MRI; Multiparametric UltraSound; Prostate cancer; Shear wave elastography.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Contrast Media
  • Elasticity Imaging Techniques / methods*
  • Humans
  • Male
  • Prostatic Neoplasms / diagnostic imaging*
  • Reproducibility of Results
  • Ultrasonography, Doppler / methods*


  • Contrast Media