IBD and the gut microbiota--from bench to personalized medicine

Curr Gastroenterol Rep. 2015 Apr;17(4):15. doi: 10.1007/s11894-015-0439-z.


Inflammatory bowel diseases (IBD) are chronic relapsing inflammatory disorders involving the gastrointestinal (GI) tract, which arise from the confluence of genetic, immunological, microbial, and environmental factors. Clinical, genetic, and experimental data support the role of gut microbiota in contributing to the etiopathogenesis of these diseases. In IBD, the development of gut dysbiosis and imbalances in host-microbe relationships contribute to the extent, severity, and chronicity of intestinal inflammation. With continued advances in knowledge, technology, bioinformatics tools, and capabilities to define disease subsets, we will be able to lower risk and improve clinical outcomes in IBD through individualized interventions that restore host-microbial balance. This article provides a critical review of the field, based on the latest clinical and experimental information.

Publication types

  • Review

MeSH terms

  • Diet / adverse effects
  • Dysbiosis
  • Genetic Predisposition to Disease
  • Host-Pathogen Interactions
  • Humans
  • Inflammatory Bowel Diseases / etiology
  • Inflammatory Bowel Diseases / microbiology*
  • Inflammatory Bowel Diseases / therapy
  • Intestines / microbiology*
  • Microbiota*
  • Precision Medicine / methods*
  • Probiotics
  • Risk Factors