In this review we discuss the molecular mechanisms of insulin resistance concomitant with metabolic inflammation. We also analyze the world results of experimental and clinical studies which aimed at identifying the molecular targets for the development of new prevention and treatment of insulin resistance.
V obzore rassmotreny molekuliarnye mekhanizmy formirovaniia insulinorezistentnosti na fone metabolicheskogo vospaleniia; proanalizirovany rezul'taty éksperimental'nykh i klinicheskikh rabot, napravlennykh na vyiavlenie molekuliarnykh misheneĭ s tsel'iu razrabotki novykh metodov profilaktiki i lecheniia insulinorezistentnosti.
Keywords: insulin resistance; metabolic syndrome; obesity; type 2 diabetes.