miR2GO: comparative functional analysis for microRNAs

Bioinformatics. 2015 Jul 15;31(14):2403-5. doi: 10.1093/bioinformatics/btv140. Epub 2015 Mar 10.

Abstract

miR2GO is a web-based platform for comparative analyses of human miRNA functions. It includes two programs: miRmut2GO and miRpair2GO. miRmut2GO implements a knowledge-based method to assess the functional effects of genetic and somatic mutations in microRNA seed regions. The functional effects of a mutation are analysed by semantic comparison of enriched gene ontology (GO) annotations of the target gene sets for the wild-type and mutated alleles. miRpair2GO compares the functions of two different miRNAs based on the enriched functional annotations of their target gene sets.

Availability and implementation: The miR2GO web server is available at http://compbio.uthsc.edu/miR2GO.

MeSH terms

  • Gene Ontology
  • Humans
  • MicroRNAs / chemistry*
  • MicroRNAs / metabolism
  • Molecular Sequence Annotation
  • Mutation*
  • Software*

Substances

  • MicroRNAs