Abstract
Novel spirooxindole-pyrazolines and spirobenzofuranone-pyrazolines have been synthesized in good to excellent yields via the annulation reactions of the corresponding 3-alkylideneoxindoles and 3-alkylidenebenzofuranones with Huisgen zwitterions. The preliminary bioassay demonstrated that some of the spiropyrazolines possess good in vitro fungicidal activity against several crop fungi at a concentration of 50 μg mL(-1).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Benzofurans / chemical synthesis
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Benzofurans / chemistry
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Benzofurans / pharmacology*
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Dose-Response Relationship, Drug
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Fungi / drug effects*
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Indoles / chemical synthesis
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Indoles / chemistry
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Indoles / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Oxindoles
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Spiro Compounds / chemical synthesis
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology*
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Structure-Activity Relationship
Substances
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Antifungal Agents
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Benzofurans
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Indoles
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Oxindoles
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Pyrazoles
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Spiro Compounds
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2-oxindole