ChIPseeker: An R/Bioconductor Package for ChIP Peak Annotation, Comparison and Visualization

Bioinformatics. 2015 Jul 15;31(14):2382-3. doi: 10.1093/bioinformatics/btv145. Epub 2015 Mar 11.

Abstract

ChIPseeker is an R package for annotating ChIP-seq data analysis. It supports annotating ChIP peaks and provides functions to visualize ChIP peaks coverage over chromosomes and profiles of peaks binding to TSS regions. Comparison of ChIP peak profiles and annotation are also supported. Moreover, it supports evaluating significant overlap among ChIP-seq datasets. Currently, ChIPseeker contains 15 000 bed file information from GEO database. These datasets can be downloaded and compare with user's own data to explore significant overlap datasets for inferring co-regulation or transcription factor complex for further investigation.

Availability and implementation: ChIPseeker is released under Artistic-2.0 License. The source code and documents are freely available through Bioconductor (http://www.bioconductor.org/packages/release/bioc/html/ChIPseeker.html).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Chromatin Immunoprecipitation*
  • Computer Graphics
  • DNA / chemistry
  • DNA / metabolism
  • High-Throughput Nucleotide Sequencing*
  • Molecular Sequence Annotation
  • Sequence Analysis, DNA*
  • Software*
  • Transcription Factors / metabolism*
  • Transcription Initiation Site

Substances

  • Transcription Factors
  • DNA