Time-restricted feeding attenuates age-related cardiac decline in Drosophila

Science. 2015 Mar 13;347(6227):1265-9. doi: 10.1126/science.1256682.


Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Drosophila melanogaster. We detected improved sleep, prevention of body weight gain, and deceleration of cardiac aging under TRF, even when caloric intake and activity were unchanged. We used temporal gene expression profiling and validation through classical genetics to identify the TCP-1 ring complex (TRiC) chaperonin, the mitochondrial electron transport chain complexes, and the circadian clock as pathways mediating the benefits of TRF.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chaperonins / genetics
  • Chaperonins / metabolism
  • Circadian Clocks*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / physiology*
  • Electron Transport
  • Energy Intake
  • Feeding Behavior
  • Flight, Animal
  • Heart / physiology
  • Male
  • Metabolic Networks and Pathways
  • Mitochondria / metabolism
  • Myocardial Contraction
  • Sleep
  • Transcriptome
  • Weight Gain


  • Drosophila Proteins
  • Chaperonins