Regional therapies for in-transit disease

Surg Oncol Clin N Am. 2015 Apr;24(2):309-22. doi: 10.1016/j.soc.2014.12.008. Epub 2015 Jan 30.


In-transit melanoma is an uncommon pattern of recurrence, but presents unique management challenges and opportunities for treatment. The clinical presentation usually involves from 1 to more than 100 small subcutaneous or cutaneous nodules, ranging from submillimeter to multiple centimeters in diameter. Regional chemotherapy techniques are a mainstay of treatment of patients without systemic disease spread. Future applications of regional therapy are likely to involve combination therapy with cytotoxic agents and novel immune modulators. Regional therapy provides distinct opportunities for the treatment of unresectable disease, and offers a unique platform for investigation of novel therapeutics in early-stage clinical trials.

Keywords: In-transit melanoma; Isolated limb infusion; Isolated limb perfusion; Regional therapy.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Chemotherapy, Cancer, Regional Perfusion
  • Humans
  • Melanoma / pathology
  • Melanoma / therapy*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / therapy*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy*


  • Antineoplastic Agents