Overview of proteomics studies in obstructive sleep apnea

Sleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb 14.


Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.

Keywords: Biomarkers; Lung; Mass spectrometry; Metabolic disorders; Obstructive sleep apnea; Proteomics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Biomarkers / blood
  • Biomarkers / urine
  • Child
  • Humans
  • Proteomics* / methods
  • Sleep Apnea, Obstructive / blood
  • Sleep Apnea, Obstructive / diagnosis*
  • Sleep Apnea, Obstructive / urine


  • Biomarkers