[Retinal vascular beta-adrenergic receptors in man]

Ophtalmologie. Jan-Mar 1989;3(1):62-4.
[Article in French]

Abstract

Beta-blockers are widely used in the primary open angle glaucoma treatment. The molecular mechanism by which these drugs reduce intraocular pressure is essentially based on the blockade of beta-adrenergic receptors localized on the ciliary processes. Vascular effects of beta-blockers, which are difficult to exhibit clinically, have been recently reported for some drugs with intrinsic sympathomimetic activity. In this study, we attempted to investigate the presence of beta-adrenergic specific binding sites on the human retinal vessels, by means of an in vitro autoradiographic technique. These receptors are localized both on arteries and veins; displacement studies indicated that they are mainly of beta-2 subtype.

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology
  • Aged
  • Aged, 80 and over
  • Autoradiography / methods*
  • Humans
  • Middle Aged
  • Radiography
  • Receptors, Adrenergic, beta / analysis*
  • Receptors, Adrenergic, beta / drug effects
  • Retinal Vessels / analysis*
  • Retinal Vessels / diagnostic imaging

Substances

  • Adrenergic beta-Antagonists
  • Receptors, Adrenergic, beta