FamLinkX - implementation of a general model for likelihood computations for X-chromosomal marker data

Forensic Sci Int Genet. 2015 Jul;17:1-7. doi: 10.1016/j.fsigen.2015.02.007. Epub 2015 Feb 21.


The use of genetic markers located on the X chromosome has seen a significant increase in the last years and their utility has been well studied. This paper describes the software FamLinkX, freely available at http://www.famlink.se, implementing a new algorithm for likelihood computations accounting for linkage, linkage disequilibrium and mutations. It is obvious that such software is sought for among forensic users as more and more X-chromosomal markers become available. We provide some simulated examples demonstrating the utility of the implementation as well as its application in forensic casework. Though algebraic derivations are generally unfeasible, the paper outlines some theoretical considerations and provides a discussion on the validation of the software. The focus of this paper is to compare the software to existing methods in a forensic setting, perform a validation study as well as to provide an idea of the discriminatory power for X-chromosomal markers.

Keywords: FamLinkX; Linkage; Linkage disequilibrium; Mutations; X chromosome.

Publication types

  • Validation Study

MeSH terms

  • Algorithms
  • Chromosome Mapping
  • Chromosomes, Human, X*
  • Forensic Genetics / methods*
  • Genes, X-Linked*
  • Genetic Linkage
  • Genetic Markers / genetics
  • Humans
  • Likelihood Functions
  • Linkage Disequilibrium
  • Models, Genetic*
  • Mutation
  • Software


  • Genetic Markers