Intraepithelial lymphocytes contain virus-specific, MHC-restricted cytotoxic cell precursors after gut mucosal immunization with reovirus serotype 1/Lang

Reg Immunol. 1989 Mar-Apr;2(2):98-102.


Reovirus 1 has been intraduodenally administered to mice to determine whether virus-specific cytotoxic cells can be elicited within the intestinal epithelium. We have found that reovirus-stimulated, but not control mice, generate virus-specific cytotoxic effector cells when isolated intraepithelial lymphocytes are restimulated in vitro. These effector cells are restricted by major histocompatibility complex (MHC) class I determinants and thus appear to utilize the T cell antigen receptor and to be of the T cell lineage. These results raise the possibility that cytotoxic T lymphocytes (CTL) may be an important component of the host immune response in the intestinal epithelium.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Differentiation, T-Lymphocyte / analysis
  • Antigens, Surface / analysis
  • CD8 Antigens
  • Cell Differentiation
  • Cytotoxicity, Immunologic
  • Duodenum / cytology
  • Duodenum / immunology*
  • Epithelial Cells
  • Epithelium / immunology
  • Immunization
  • Mice
  • Mice, Inbred BALB C / immunology
  • Mice, Inbred C3H / immunology
  • Reoviridae / immunology*
  • T-Lymphocytes, Cytotoxic / immunology*
  • Thy-1 Antigens


  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • CD8 Antigens
  • Thy-1 Antigens