Inflammasome control of viral infection

Curr Opin Virol. 2015 Jun;12:38-46. doi: 10.1016/j.coviro.2015.02.007. Epub 2015 Mar 12.

Abstract

The inflammasome is a caspase-1 containing complex that activates the proinflammatory cytokines IL-1β and IL-18 and results in the proinflammatory cell death known as pyroptosis. Numerous recent publications have highlighted the importance of inflammasome activation in the control of virus infection. Inflammasome activation during viral infection is dependent on a variety of upstream receptors including the NOD-like receptor, RIG-I-like receptor and AIM2-like receptor families. Various receptors also function in inflammasome activation in different cellular compartments, including the cytoplasm and the nucleus. The effectiveness of inflammasomes at suppressing virus replication is highlighted by the prevalence and diversity of virus encoded inflammasome inhibitors. Also, the host has a myriad of regulatory mechanisms in place to prevent unwanted inflammasome activation and overt inflammation. Finally, recent reports begin to suggest that inflammasome activation and inflammasome modulation may have important clinical applications. Herein, we highlight recent advances and discuss potential future directions toward understanding the role of inflammasomes during virus infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / immunology
  • Humans
  • Inflammasomes / genetics
  • Inflammasomes / immunology*
  • Inflammasomes / metabolism*
  • Virus Diseases / immunology*
  • Virus Diseases / metabolism
  • Virus Diseases / virology
  • Virus Replication

Substances

  • Inflammasomes
  • DDX58 protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases