Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling

Cell Mol Life Sci. 2015 Jul;72(13):2535-44. doi: 10.1007/s00018-015-1882-6. Epub 2015 Mar 13.

Abstract

SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / chemistry
  • Adaptor Proteins, Signal Transducing / immunology*
  • Adaptor Proteins, Signal Transducing / metabolism
  • Gene Components
  • Humans
  • Models, Biological*
  • Models, Molecular*
  • Neoplasms / immunology*
  • Neoplasms / metabolism
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins pp60(c-src) / chemistry
  • Proto-Oncogene Proteins pp60(c-src) / immunology*
  • Proto-Oncogene Proteins pp60(c-src) / metabolism
  • Receptors, Antigen, B-Cell / metabolism
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction / immunology*

Substances

  • Adaptor Proteins, Signal Transducing
  • Receptors, Antigen, B-Cell
  • Receptors, Cell Surface
  • SLA protein, human
  • Proto-Oncogene Proteins pp60(c-src)