Ophthalmology issues in schizophrenia

Curr Psychiatry Rep. 2015 May;17(5):28. doi: 10.1007/s11920-015-0569-x.


Schizophrenia is a complex mental disorder associated with not only cognitive dysfunctions, such as memory and attention deficits, but also changes in basic sensory processing. Although most studies on schizophrenia have focused on disturbances in higher-order brain functions associated with the prefrontal cortex or frontal cortex, recent investigations have also reported abnormalities in low-level sensory processes, such as the visual system. At very early stages of the disease, schizophrenia patients frequently describe in detail symptoms of a disturbance in various aspects of visual perception that may lead to worse clinical symptoms and decrease in quality of life. Therefore, the aim of this review is to describe the various studies that have explored the visual issues in schizophrenia.

Publication types

  • Review

MeSH terms

  • Convergence, Ocular
  • Dopamine / metabolism
  • Edinger-Westphal Nucleus / pathology
  • Endophenotypes
  • Eye Movements*
  • Frontal Lobe / physiopathology
  • Glutamine / metabolism
  • Humans
  • Neuropsychological Tests
  • Prefrontal Cortex / physiopathology
  • Pursuit, Smooth
  • Quality of Life
  • Retina / pathology*
  • Saccades
  • Schizophrenia / metabolism
  • Schizophrenia / pathology*
  • Schizophrenia / physiopathology*
  • Visual Pathways / pathology*
  • Visual Pathways / physiopathology*
  • Visual Perception*


  • Glutamine
  • Dopamine