Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation

Ann N Y Acad Sci. 2015 Jul;1347:45-51. doi: 10.1111/nyas.12726. Epub 2015 Mar 13.


Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin-2 (Ang-2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang-2 is upregulated in multiple inflammatory diseases and has been implicated in the direct control of inflammation-related signaling pathways. As a consequence of its multiple roles, designs for therapeutic targeting of Ang-2 should consider the dual function of this factor in regulating angiogenesis and inflammation.

Keywords: Ang-2; angiopoietin; inflammation; innate immune cell; myeloid cell.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiopoietin-2 / metabolism*
  • Autoimmune Diseases / immunology*
  • Endothelial Cells / immunology
  • Endothelium, Vascular / metabolism
  • Humans
  • Inflammation / immunology*
  • Leukocytes / immunology
  • Neoplasms / immunology*
  • Neovascularization, Physiologic / physiology*
  • Sepsis / immunology
  • Signal Transduction
  • Vascular Endothelial Growth Factor A / metabolism


  • ANGPT2 protein, human
  • Angiopoietin-2
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A