Age, gender, and topography influence the clinical and dermoscopic appearance of lentigo maligna

J Am Acad Dermatol. 2015 May;72(5):801-8. doi: 10.1016/j.jaad.2015.01.030. Epub 2015 Mar 13.

Abstract

Background: Little is known about the frequency of clinical and dermoscopic patterns of lentigo maligna (LM) in relation to specific anatomic subsites and patients characteristics.

Objective: We sought to assess the frequency of clinical and dermoscopic features of LM and to correlate them to specific anatomic subsites, and patients' age and gender.

Methods: This was a retrospective analysis of clinical and dermoscopic images of a series of consecutive, histopathologically diagnosed, facial and extrafacial LM.

Results: A total of 201 cases from 200 patients (mean age 69.51 ± 12.26 years) including 120 women were collected. Most cases were located on the face (n = 192, 95.5%). In 102 cases, LM presented as clinically solitary facial macule (s/LM), whereas it was associated with multiple surrounding freckles in the remaining cases. s/LM were significantly smaller (<10 vs >10 mm; P = .020) and associated with younger age compared with LM associated with multiple surrounding freckles (mean age 67.73 ± 12.68 years vs 71.34 ± 11.59 years, respectively; P = .036). Dermoscopically, gray color irrespective of a specific pattern was the most prevalent finding seen in 178 (88.6%) cases.

Limitations: This was a retrospective study.

Conclusions: The knowledge about patient age, patient gender, and site-related clinical features of LM associated with gray color upon dermoscopy may enhance the clinical recognition of LM.

Keywords: dermoscopy; lentigo maligna.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Dermoscopy
  • Facial Neoplasms / epidemiology
  • Facial Neoplasms / pathology
  • Female
  • Humans
  • Hutchinson's Melanotic Freckle / diagnosis
  • Hutchinson's Melanotic Freckle / epidemiology
  • Hutchinson's Melanotic Freckle / pathology*
  • Male
  • Retrospective Studies
  • Sex Factors
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / pathology*