Metabolic pathways promoting cancer cell survival and growth

Nat Cell Biol. 2015 Apr;17(4):351-9. doi: 10.1038/ncb3124. Epub 2015 Mar 16.


Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Proliferation
  • Cell Survival
  • Energy Metabolism / physiology*
  • Glucose / metabolism*
  • Humans
  • Lipid Metabolism / physiology*
  • Metabolic Networks and Pathways / physiology*
  • Mice
  • Neoplasms / metabolism*
  • Oncogenes


  • Glucose