Feverfew was already known at the beginning of our era. In folk medicine, infusions from the leaves of Tanacetum parthenium were used in rheumatism, fever, and in migraine, menstrual pain, toothaches also digestive troubles, cough, or parasitic diseases. It has been proved that the biological activity of the plants resultsfrom the presence of the chemical compounds with different structures, including the the sesquiterpene lactones, which include partenolid, determining the antimigraine properties of plants. Research up to date on preclinical and clinical nature demonstrate the efficacy of plants in the prevention of migraine attacks. Based on the results can also conclude that the use of feverfew is safe and recorded side effects are mild and transient.