Somatostatin Secretion From Isolated Rat Pancreatic Islets

Scand J Clin Lab Invest. 1989 Apr;49(2):139-43. doi: 10.3109/00365518909105412.

Abstract

Certain aspects of somatostatin secretion from isolated rat pancreatic islets are described. A considerable, but falling basal secretion of somatostatin was observed in the pre-incubation periods. Both glucose and theophylline stimulation gave significant increases in somatostatin secretion, whereas carbachol inhibits the somatostatin secretion at 25 mmol l-1 glucose but not at 5 mmol l-1 glucose. The glucose effect on somatostatin secretion required a normoglycaemic pre-incubation level of 5.5 mmol l-1 glucose. Our results indicate that somatostatin secretion from isolated pancreatic islets is strongly dependent on the experimental conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbachol / pharmacology
  • Glucose / pharmacology
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / metabolism*
  • Rats
  • Somatostatin / metabolism*
  • Theophylline / pharmacology

Substances

  • Somatostatin
  • Carbachol
  • Theophylline
  • Glucose