Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiency

Immunol Cell Biol. 2015 Jul;93(6):517-21. doi: 10.1038/icb.2015.32. Epub 2015 Mar 17.


DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity and mortality, and are distinguished by chronic cutaneous viral infections, including those caused by herpes simplex virus (HSV). The underlying mechanism of the specific susceptibility to these chronic cutaneous viral infections is currently unknown, largely because the effect of DOCK8 deficiency has not been studied in suitable models. A better understanding of these mechanisms is required to underpin the development of more specific therapies. Here we show that DOCK8-deficient mice have poor control of primary cutaneous herpes simplex lesions and this is associated with increased virus loads. Furthermore, DOCK8-deficient mice showed a lack of CD4(+) T-cell infiltration into HSV-infected skin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Line
  • Chemotaxis, Leukocyte* / genetics
  • Chemotaxis, Leukocyte* / immunology
  • Disease Models, Animal
  • Guanine Nucleotide Exchange Factors / deficiency*
  • Herpes Simplex / genetics*
  • Herpes Simplex / immunology*
  • Herpes Simplex / pathology
  • Herpes Simplex / virology
  • Immunity
  • Mice
  • Mice, Knockout
  • Simplexvirus / immunology*
  • Skin / immunology*
  • Skin / pathology*
  • Skin / virology
  • Viral Load


  • Dock8 protein, mouse
  • Guanine Nucleotide Exchange Factors