Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study

Int J Dermatol. 2015 Jun;54(6):730-5. doi: 10.1111/ijd.12650. Epub 2015 Mar 16.


Background: Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of alopecia using ADSC-CM.

Objectives: This study evaluates our clinical experience in the use of ADSC-CM for the treatment of FPHL.

Methods: A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC-CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed.

Results: The application of ADSC-CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm(2) (P < 0.001). Hair thickness increased from 57.5 μm to 64.0 μm (P < 0.001). None of the patients reported severe adverse reactions.

Conclusions: The application of ADSC-CM is a potential treatment option for FPHL.

Publication types

  • Clinical Study

MeSH terms

  • Adipose Tissue / cytology*
  • Adult
  • Aged
  • Alopecia / surgery*
  • Culture Media, Conditioned*
  • Female
  • Humans
  • Middle Aged
  • Retrospective Studies
  • Stem Cell Transplantation*
  • Young Adult


  • Culture Media, Conditioned