Nootropic effect of meadowsweet (Filipendula vulgaris) extracts

Bull Exp Biol Med. 2015 Mar;158(5):659-63. doi: 10.1007/s10517-015-2841-9. Epub 2015 Mar 17.

Abstract

The effects of the extracts of the aboveground parts of Filipendula vulgaris Moench on the behavior and memory of mice after hypoxic injury and their physical performance in the open-field test were studied using the models of hypoxia in a sealed volume, conditioned passive avoidance response (CPAR), and forced swimming with a load. The extracts improved animal resistance to hypoxia, normalized orientation and exploration activities, promoted CPAR retention after hypoxic injury, and increased physical performance. Aqueous extract of meadowsweet had the most pronounced effect that corresponded to the effect of the reference drug piracetam. These effects were probably caused by modulation of hippocampal activity.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Filipendula / chemistry*
  • Male
  • Mice
  • Nootropic Agents / chemistry*
  • Nootropic Agents / pharmacology*
  • Piracetam / pharmacology
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*

Substances

  • Nootropic Agents
  • Plant Extracts
  • Piracetam