The role of phosphodiesterase inhibitors in the management of pulmonary vascular diseases

Glob Cardiol Sci Pract. 2014 Oct 16;2014(3):257-90. doi: 10.5339/gcsp.2014.42. eCollection 2014.


Phosphodiesterase inhibitors (PDE) can be used as therapeutic agents for various diseases such as dementia, depression, schizophrenia and erectile dysfunction in men, as well as congestive heart failure, chronic obstructive pulmonary disease, rheumatoid arthritis, other inflammatory diseases, diabetes and various other conditions. In this review we will concentrate on one type of PDE, mainly PDE5 and its role in pulmonary vascular diseases.

Keywords: pulmonary hypertension; pulmonary phosphodiesterase inhibitors; pulmonary vascular disease.