Comparative Study
doi: 10.1007/BF02005880.
Bicuculline and picrotoxin block gamma-aminobutyric acid-gated Cl- conductance by different mechanisms
- PMID: 2578409
- DOI: 10.1007/BF02005880
Item in Clipboard
Comparative Study
Bicuculline and picrotoxin block gamma-aminobutyric acid-gated Cl- conductance by different mechanisms
Experientia.
.
Abstract
Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for gamma-aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.
Similar articles
-
Multiple mechanisms of antagonism of gamma-aminobutyric acid (GABA) responses.Cell Mol Neurobiol. 1987 Mar;7(1):97-103. doi: 10.1007/BF00734993. Cell Mol Neurobiol. 1987. PMID: 3594520
-
Antagonists of GABA responses, studied using internally perfused frog dorsal root ganglion neurons.Neuroscience. 1987 Sep;22(3):1123-33. doi: 10.1016/0306-4522(87)92987-3. Neuroscience. 1987. PMID: 2825069
-
The anion selectivity of the gamma-aminobutyric acid controlled chloride channel in the perfused spinal ganglion cell of frog.Neurosci Res. 1986 Jul;3(5):371-83. doi: 10.1016/0168-0102(86)90029-5. Neurosci Res. 1986. PMID: 2427981
-
Voltage-clamp studies of the inhibition of gamma-aminobutyric acid response by glucocorticoids in bullfrog primary afferent neurons.Brain Res. 1987 Dec 1;435(1-2):241-8. doi: 10.1016/0006-8993(87)91607-6. Brain Res. 1987. PMID: 3501326
-
[Chloride channel].Nihon Yakurigaku Zasshi. 1984 Feb;83(2):93-104. Nihon Yakurigaku Zasshi. 1984. PMID: 6086473 Review. Japanese.
Cited by
-
Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones.Br J Pharmacol. 1989 Nov;98(3):735-40. doi: 10.1111/j.1476-5381.1989.tb14600.x. Br J Pharmacol. 1989. PMID: 2574062 Free PMC article.
-
Sex differences in the sensitivity of CBA mice to convulsions induced by GABA antagonists are age-dependent.Psychopharmacology (Berl). 1987;91(2):226-9. doi: 10.1007/BF00217068. Psychopharmacology (Berl). 1987. PMID: 3107037
-
Contribution of chloride shifts to the fade of gamma-aminobutyric acid-gated currents in frog dorsal root ganglion cells.J Physiol. 1987 Oct;391:219-34. doi: 10.1113/jphysiol.1987.sp016735. J Physiol. 1987. PMID: 2451005 Free PMC article.
-
Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.J Physiol. 1996 Dec 1;497 ( Pt 2)(Pt 2):509-22. doi: 10.1113/jphysiol.1996.sp021784. J Physiol. 1996. PMID: 8961191 Free PMC article.
-
Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels.PLoS One. 2015 Apr 22;10(4):e0122629. doi: 10.1371/journal.pone.0122629. eCollection 2015. PLoS One. 2015. PMID: 25902139 Free PMC article.