Current and future applications of corneal cross-linking

Curr Opin Ophthalmol. 2015 May;26(3):206-13. doi: 10.1097/ICU.0000000000000146.


Purpose of review: To review current concepts and future directions of corneal cross-linking (CXL) as a treatment for keratoconus, ectasia after refractive surgery and infectious keratitis.

Recent findings: Several important laboratory and clinical studies have established the safety and success of corneal cross-linking for the treatment of keratoconus and other corneal ectasias. Recently, additional studies have analyzed new directions and controversies in corneal cross-linking, exploring new indications, comparing new techniques and analyzing results of new protocols.

Summary: The results of bench and clinical research are providing the foundation to allow for protocol modifications of the standard cross-linking protocols and expansion of cross-linking concepts for techniques such as accelerated cross-linking, epithelium-sparing protocols and measurement of progression and success.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Collagen / metabolism*
  • Corneal Stroma / metabolism*
  • Cross-Linking Reagents / therapeutic use*
  • Humans
  • Keratoconus / drug therapy*
  • Keratoconus / metabolism
  • Photosensitizing Agents / therapeutic use*
  • Riboflavin / therapeutic use
  • Ultraviolet Rays


  • Cross-Linking Reagents
  • Photosensitizing Agents
  • Collagen
  • Riboflavin