Signalling scaffolds and local organization of cellular behaviour

Nat Rev Mol Cell Biol. 2015 Apr;16(4):232-44. doi: 10.1038/nrm3966. Epub 2015 Mar 18.


Cellular responses to environmental cues involve the mobilization of GTPases, protein kinases and phosphoprotein phosphatases. The spatial organization of these signalling enzymes by scaffold proteins helps to guide the flow of molecular information. Allosteric modulation of scaffolded enzymes can alter their catalytic activity or sensitivity to second messengers in a manner that augments, insulates or terminates local cellular events. This Review examines the features of scaffold proteins and highlights examples of locally organized groups of signalling enzymes that drive essential physiological processes, including hormone action, heart rate, cell division, organelle movement and synaptic transmission.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena*
  • Cells / enzymology
  • Genes, Switch / genetics
  • Humans
  • Models, Biological
  • Nuclear Matrix-Associated Proteins / metabolism*
  • Signal Transduction*


  • Nuclear Matrix-Associated Proteins