Complete nucleotide sequence of the AIDS virus, HTLV-III

Nature. 1985 Jan 24-30;313(6000):277-84. doi: 10.1038/313277a0.


The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3'-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome* / etiology
  • Amino Acid Sequence
  • Base Sequence
  • Capsid / genetics
  • DNA, Viral*
  • Deltaretrovirus / genetics*
  • Genes, Viral
  • Humans
  • Peptide Hydrolases / genetics
  • Protein Precursors / genetics
  • RNA-Directed DNA Polymerase / genetics
  • Retroviridae Infections
  • Viral Envelope Proteins / genetics
  • Viral Proteins / genetics


  • DNA, Viral
  • Protein Precursors
  • Viral Envelope Proteins
  • Viral Proteins
  • RNA-Directed DNA Polymerase
  • Peptide Hydrolases

Associated data

  • GENBANK/K02008
  • GENBANK/K02009
  • GENBANK/K02010
  • GENBANK/K02011
  • GENBANK/K02012
  • GENBANK/K03455
  • GENBANK/M15653
  • GENBANK/M15654