Pernicious anaemia presenting as hyperpigmentation

Clin Exp Dermatol. 2015 Aug;40(6):626-8. doi: 10.1111/ced.12600. Epub 2015 Mar 18.


An adult East Asian woman presented with sudden onset of hyperpigmented macules on her oral mucosal surfaces, palms and soles, in association with hypoguesia and loss of weight. This was found to be associated with underlying severe vitamin B12 deficiency secondary to pernicious anaemia.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Pernicious / complications*
  • Diagnosis, Differential
  • Female
  • Foot Dermatoses / etiology*
  • Hand Dermatoses / etiology*
  • Humans
  • Hyperpigmentation / etiology*
  • Middle Aged
  • Mouth Diseases / etiology*
  • Mouth Mucosa / pathology