Intrinsic excitability of human motoneurons in biceps brachii versus triceps brachii

J Neurophysiol. 2015 Jun 1;113(10):3692-9. doi: 10.1152/jn.00960.2014. Epub 2015 Mar 18.


The intrinsic excitability of spinal motoneurons is mediated in part by the presence of persistent inward currents (PICs), which amplify synaptic input and promote self-sustained firing. Studies using animal models have shown that PICs are greater in extensor motoneurons over flexor motoneurons, but this difference has not yet been demonstrated in humans. The primary objective of this study was to determine whether a similar difference exists in humans by recording from motor units in biceps and triceps brachii during isometric contractions. We compared firing rate profiles of pairs of motor units, in which the firing rate of the lower-threshold "control" unit was used as an indicator of common drive to the higher-threshold "test" unit. The estimated contribution of the PIC was calculated as the difference in firing rate of the control unit at recruitment versus derecruitment of the test unit, a value known as the delta-F (ΔF). We found that ΔF values were significantly higher in triceps brachii (5.4 ± 0.9 imp/s) compared with biceps brachii (3.0 ± 1.4 imp/s; P < 0.001). This difference was still present even after controlling for saturation in firing rate of the control unit, rate modulation of the control unit, and differences in recruitment time between test and control units, which are known to contribute to ΔF variability. We conclude that human elbow flexor and extensor motor units exhibit differences in intrinsic excitability, contributing to different neural motor control strategies between muscle groups.

Keywords: elbow extensors; elbow flexors; intrinsic excitability; motoneurons; neuromodulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Aged
  • Analysis of Variance
  • Elbow / innervation*
  • Electromyography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Neurons / physiology*
  • Muscle Contraction / physiology*
  • Muscle, Skeletal / cytology*
  • Muscle, Skeletal / physiology
  • Recruitment, Neurophysiological / physiology
  • Torque