A comparative histopathological study of vocal fold polyps in smokers versus non-smokers

J Laryngol Otol. 2015 May;129(5):484-8. doi: 10.1017/S002221511500064X. Epub 2015 Mar 19.

Abstract

Background: A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been performed.

Methods: A prospective histopathological study of vocal fold polyps excised from 29 patients was undertaken. This comprised a comparative analysis of polyp histopathology in smokers versus non-smokers and a review of the pertinent literature.

Results: Vocal fold polyps were larger in smokers than in non-smokers. Histopathological features significantly associated with the polyps of smokers versus those of non-smokers were increased keratinisation, dysplasia, a basement membrane thinning and hyaline degeneration.

Conclusion: Cigarette smoke has an injurious effect on vocal fold polyp epithelium and leads to increased hyaline degeneration in polyps.

Keywords: Histopathology; Polyps; Smoking; Vocal fold.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Humans
  • Hyaline Cartilage / pathology
  • Hyperplasia
  • Laryngeal Mucosa / pathology
  • Male
  • Middle Aged
  • Polyps / pathology*
  • Prospective Studies
  • Smoking / adverse effects
  • Smoking / pathology*
  • Vocal Cords / pathology*
  • Young Adult