Role of endogenous pain modulation in chronic pain mechanisms and treatment

doi:10.1097/01.j.pain.0000460343.46847.58

Review

. 2015 Apr:156 Suppl 1:S24-S31.

doi: 10.1097/01.j.pain.0000460343.46847.58.

Role of endogenous pain modulation in chronic pain mechanisms and treatment

David Yarnitsky¹

Affiliations

PMID: 25789433
DOI: 10.1097/01.j.pain.0000460343.46847.58

Review

Role of endogenous pain modulation in chronic pain mechanisms and treatment

David Yarnitsky. Pain. 2015 Apr.

. 2015 Apr:156 Suppl 1:S24-S31.

doi: 10.1097/01.j.pain.0000460343.46847.58.

Author

David Yarnitsky¹

Affiliation

¹ Department of Neurology, Rambam Health Care Campus, and Clinical Neurophysiology Laboratory, Technion Faculty of Medicine, Haifa, Israel.

PMID: 25789433
DOI: 10.1097/01.j.pain.0000460343.46847.58

Abstract

Development and application of psychophysical test paradigms to assess endogenous pain modulation in healthy controls and in patients yielded large body of data over the last 2 decades. These tests can assist in predicting pain acquisition, in characterizing pain syndromes and related dysfunctions of pain modulation, and in predicting response to treatment. This chapter reviews the development of thought on pain modulation in the clinical setup, focusing on conditioned pain modulation, and update on accumulated data regarding the mechanism, protocols of administration, and applications in the clinic.

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References

1. Abrishami A, Chan J, Chung F, Wong J. Preoperative pain sensitivity and its correlation with postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology 2011;114:445–57.
1. Arendt-Nielsen L, Andresen T, Malver LP, Oksche A, Mansikka H, Drewes AM. A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. Clin J Pain 2012;28:623–7.
1. Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. PAIN 2010;149:573–81.
1. Baba Y, Kohase H, Oono Y, Fujii-Abe K, Arendt-Nielsen L. Effects of dexmedetomidine on conditioned pain modulation in humans. Eur J Pain 2012;16:1137–47.
1. Biurrun Manresa JA, Fritsche R, Vuilleumier PH, Oehler C, Morch CD, Arendt-Nielsen L, Andersen OK, Curatolo M. Is the conditioned pain modulation paradigm reliable? A test-retest assessment using the nociceptive withdrawal reflex. PLoS One 2014;9:e100241.

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[1] Abrishami A, Chan J, Chung F, Wong J. Preoperative pain sensitivity and its correlation with postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology 2011;114:445–57.

[2] Abrishami A, Chan J, Chung F, Wong J. Preoperative pain sensitivity and its correlation with postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology 2011;114:445–57.

[3] Arendt-Nielsen L, Andresen T, Malver LP, Oksche A, Mansikka H, Drewes AM. A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. Clin J Pain 2012;28:623–7.

[4] Arendt-Nielsen L, Andresen T, Malver LP, Oksche A, Mansikka H, Drewes AM. A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. Clin J Pain 2012;28:623–7.

[5] Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. PAIN 2010;149:573–81.

[6] Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. PAIN 2010;149:573–81.

[7] Baba Y, Kohase H, Oono Y, Fujii-Abe K, Arendt-Nielsen L. Effects of dexmedetomidine on conditioned pain modulation in humans. Eur J Pain 2012;16:1137–47.

[8] Baba Y, Kohase H, Oono Y, Fujii-Abe K, Arendt-Nielsen L. Effects of dexmedetomidine on conditioned pain modulation in humans. Eur J Pain 2012;16:1137–47.

[9] Biurrun Manresa JA, Fritsche R, Vuilleumier PH, Oehler C, Morch CD, Arendt-Nielsen L, Andersen OK, Curatolo M. Is the conditioned pain modulation paradigm reliable? A test-retest assessment using the nociceptive withdrawal reflex. PLoS One 2014;9:e100241.

[10] Biurrun Manresa JA, Fritsche R, Vuilleumier PH, Oehler C, Morch CD, Arendt-Nielsen L, Andersen OK, Curatolo M. Is the conditioned pain modulation paradigm reliable? A test-retest assessment using the nociceptive withdrawal reflex. PLoS One 2014;9:e100241.

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Role of endogenous pain modulation in chronic pain mechanisms and treatment

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Role of endogenous pain modulation in chronic pain mechanisms and treatment

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