Epidemiological trends of dengue disease in Colombia (2000-2011): a systematic review

PLoS Negl Trop Dis. 2015 Mar 19;9(3):e0003499. doi: 10.1371/journal.pntd.0003499. eCollection 2015 Mar.


A systematic literature review was conducted to describe the epidemiology of dengue disease in Colombia. Searches of published literature in epidemiological studies of dengue disease encompassing the terms "dengue", "epidemiology," and "Colombia" were conducted. Studies in English or Spanish published between 1 January 2000 and 23 February 2012 were included. The searches identified 225 relevant citations, 30 of which fulfilled the inclusion criteria defined in the review protocol. The epidemiology of dengue disease in Colombia was characterized by a stable "baseline" annual number of dengue fever cases, with major outbreaks in 2001-2003 and 2010. The geographical spread of dengue disease cases showed a steady increase, with most of the country affected by the 2010 outbreak. The majority of dengue disease recorded during the review period was among those <15 years of age. Gaps identified in epidemiological knowledge regarding dengue disease in Colombia may provide several avenues for future research, namely studies of asymptomatic dengue virus infection, primary versus secondary infections, and under-reporting of the disease. Improved understanding of the factors that determine disease expression and enable improvement in disease control and management is also important.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Coinfection / epidemiology
  • Colombia / epidemiology
  • Dengue / epidemiology*
  • Dengue / prevention & control
  • Dengue / therapy
  • Disease Outbreaks
  • Female
  • Geography
  • Humans

Grant support

Sanofi Pasteur sponsored this survey and analysis. The Literature Review Group (including members of Sanofi Pasteur) were responsible for the conception of the literature analysis, development of the protocol, data collection, analysis and interpretation of data, provision of critical comments, writing the paper and approving the final version to be published.