Determining the role of microRNAs in psychiatric disorders

Nat Rev Neurosci. 2015 Apr;16(4):201-12. doi: 10.1038/nrn3879.


Recent studies have revealed that patients with psychiatric disorders have altered microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal studies have shown that manipulating the levels of particular miRNAs in the brain can alter behaviour. Here, we review recent studies in humans, animal models, cellular systems and bioinformatics that have advanced our understanding of the contribution of brain miRNAs to the regulation of behaviour in the context of psychiatric conditions. These studies highlight the potential of miRNA levels to be used in the diagnosis of psychiatric disorders and suggest that brain miRNAs could become novel treatment targets for psychiatric disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Behavior / physiology*
  • Brain / metabolism*
  • Humans
  • Mental Disorders / genetics*
  • Mental Disorders / metabolism
  • MicroRNAs / genetics*


  • MicroRNAs