Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens

Nature. 1985 Mar 7-13;314(6006):53-7. doi: 10.1038/314053a0.

Abstract

The hope that hybridoma antibodies would reveal unique cell surface antigens during embryogenesis, differentiation and oncogenesis has been replaced by the realization that such antigens are mainly carbohydrate structures of glycoproteins and glycolipids occurring in many cell types. These findings either may reflect limitations in the methods of selection of hybridoma antibodies or may point to important roles for the diverse carbohydrate structures as receptors for regulators of cell growth and differentiation.

MeSH terms

  • Antibodies, Monoclonal*
  • Antigens, Neoplasm / immunology*
  • Blood Group Antigens / immunology
  • Carbohydrate Sequence
  • Carbohydrates / immunology*
  • Cell Differentiation
  • Cell Division
  • Epitopes
  • Glycolipids / immunology*
  • Glycoproteins / immunology*
  • Humans
  • Sialoglycoproteins / immunology

Substances

  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Blood Group Antigens
  • Carbohydrates
  • Epitopes
  • Glycolipids
  • Glycoproteins
  • Sialoglycoproteins
  • oncofetal antigens