Curcumin loaded PLGA-poloxamer blend nanoparticles induce cell cycle arrest in mesothelioma cells

Eur J Pharm Biopharm. 2015 Jun;93:37-45. doi: 10.1016/j.ejpb.2015.03.005. Epub 2015 Mar 17.


The pharmacological potential of curcumin (CURC) is severely restricted because of its low water solubility/absorption, short half-life and poor bioavailability. To overcome these issues, CURC-loaded nanoparticles (NPs) were produced by a double emulsion technique. In particular, NPs were made up of an amphiphilic blend of poloxamers and PLGA to confer stealth properties to the NPs to take advantage of the enhanced permeability and retention (EPR) effect. Different surface properties of NPs made up of bare PLGA and PLGA/poloxamer blend were confirmed by the different interactions of these NPs with serum proteins and also by their ability to be internalized by mesothelioma cell line. The uptake of PLGA/poloxamer NPs induces a persistent block in G0/G1 phase of the cell cycle up to 72 h, thus overcoming the drug tolerance phenomenon, normally evidenced with free CURC.

Keywords: Curcumin; Mesothelioma; Nanoparticles; PLGA; Poloxamers; Stealth.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / metabolism
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Cycle Checkpoints / drug effects*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Chemistry, Pharmaceutical
  • Curcumin / chemistry
  • Curcumin / metabolism
  • Curcumin / pharmacology*
  • Drug Carriers*
  • Drug Stability
  • Drug Tolerance
  • Humans
  • Kinetics
  • Lactic Acid / chemistry*
  • Mesothelioma / drug therapy*
  • Mesothelioma / pathology
  • Nanomedicine
  • Nanoparticles*
  • Particle Size
  • Poloxamer / chemistry*
  • Polyglycolic Acid / chemistry*
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Protein Binding
  • Solubility
  • Surface Properties
  • Technology, Pharmaceutical / methods


  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • Poloxamer
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Curcumin