Reduced dosage of bevacizumab in treatment of vestibular schwannomas in patients with neurofibromatosis type 2

Eur Arch Otorhinolaryngol. 2015 Dec;272(12):3857-60. doi: 10.1007/s00405-015-3604-y. Epub 2015 Mar 21.


Neurofibromatosis type 2 (NF2) is a tumor suppressor syndrome associated with vestibular schwannomas and other benign tumors of the central nervous system. Bevacizumab is used for treatment of progressive vestibular schwannomas, with the intent to reduce tumor size or preserve/improve hearing. Prolonged treatment can cause side effects such as hypertension and proteinuria, which can be cause for discontinuation of therapy. We report on 3 patients who were treated with bevacizumab for 66-76 months, with dose reductions that minimized side effects while sustaining the clinical effect of the antiangiogenic therapy. After dose reduction from 5 mg/kg bi- or tri-weekly to 2.5 mg bi- or tri-weekly, all patients appeared clinically stable and radiographic and audiologic follow-up showed sustained response. In conclusion, in some NF2 patients, dose reduction of bevacizumab seems to be an effective option for managing side effects.

Keywords: Bevacizumab; Dose reduction; NF2; Neurofibromatosis; VEGF; Vestibular schwannoma.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Angiogenesis Inhibitors / administration & dosage*
  • Bevacizumab / administration & dosage*
  • Dose-Response Relationship, Drug
  • Female
  • Hearing Loss / etiology
  • Hearing Loss / prevention & control
  • Humans
  • Male
  • Neurofibromatosis 2 / complications*
  • Neuroma, Acoustic / drug therapy*


  • Angiogenesis Inhibitors
  • Bevacizumab